Cristal Therapeutics announces a publication in ‘Chemical Science’ on CliCr® technology platform, comprising a new class of superior copper free click reagents for conjugation of small molecules, biologics, nanoparticles and other moieties
Maastricht, The Netherlands, 29 September 2020
Cristal Therapeutics, a Dutch phase 2 clinical-stage pharmaceutical company developing targeted nanomedicines for the treatment of cancer and other diseases with high unmet patient need, announces publication in Chemical Science, the flagship journal of the Royal Society of Chemistry, of an article on the development of TMTHSI as part of the CliCr® platform providing fast and versatile conjugation tools.
For the optimal performance of CriPec® nanomedicines, it is essential to be able to attach a broad range of small molecule active agents and large molecular entities, biologics, to CriPec® nanoparticles.
CliCr® is also used to generate virus mimicking nanoparticles. CriVac® is a unique antigen carrier platform based on CriPec® nanoparticles that, in contrast to viral vectors, do not convey a bystander immune response. CriPec particles’ size resemble a virus and the desired numbers of antigen displayed on its surface are controlled via CliCr®. CriVac® mimics features of a live virus in a tailored manner to induce immunity safely, efficiently and solely to the displayed antigen, offering a prophylactic vaccination strategy which will be readily adaptable to different pathogenic treats.
The very attractive functionalisation possibilities, combined with its versatility, great reactivity and small size offer multiple opportunities for CliCr® reagents to become the new standard for non-copper catalyzed click reactions in a multitude of applications.
Dr Cristianne Rijcken, CSO of Cristal Therapeutics, stated:
“This new versatile click reagent originates from an intense collaboration between industry and academic partners. For our nanomedicine applications, a fast, cleanly reacting and small click reagent is absolutely indispensable. These demands required the development of a new reagent, which will be highly attractive both for our proprietary applications and for the wider world of the biological, medical and material science applications. This is ground-breaking technology!”
Please read the full press release.